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pentobarbital will improve the stage or influence of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of ivosidenib with robust CYP3A4 inducers reduced ivosidenib plasma concentrations.pentobarbital decreases amounts of elvitegravir/cobicistat/emtricitabine/tenofovir DF by im